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Ekstruderji se uporabljajo za natančno in kvalitetno mešanje, stiskanje in procesiranje viskozne snovi. Tako jih v laboratorijih uporabljamo za simuliranje in optimizacijo proizvodnega procesa, medtem ko pri farmacevtskih raziskavah, razvoju in produkciji uporabljamo ekstruderje z dvojnim vijakom (Twin-Screw Extruders) za visoko-temperaturno ekstrudiranje ter granulatorje z dvojnim vijakom za ponavljajočo granuliranje.

Micro kompounderji

Micro-compounders are suitable for  early material development when only a few grams of sample available for testing . For example, 5 grams is sufficient with a micro-compounder.

All micro-compounder models are equipped with a back-flow channel and a bypass valve which allow control of the residence time of the sample in the compounder. Depending on the compounder model, it is also possible to measure the relative sample viscosity at different screw speeds. When combined with a mini injection molding machine, scientists can produce specimens for further analysis from limited sample amounts.

Pharma mini HME Micro Compounder

The Thermo Scientific™ Pharma mini HME is a GMP compliant conical micro compounder for Hot Melt Extrusion in research and development in the pharmaceutical industry. When developing new drugs, shortening time-to-market and reducing waste of expensive API's and overall development costs provide a distinct competitive advantage. Hence, quick and early assessment of new API/excipient formulations is critical. Hot melt extrusion and continuous processing can lead to speedier formulation development and cost efficient production. The Thermo Scientific Pharma mini HME allows users to identify the right drug candidates for hot melt extrusion by compounding as little as three grams of material.

With the Pharma mini HME, we offer a micro twin-screw compounder which requires as little as three grams of total material to identify the right drug candidates for hot melt extrusion. The compounder with conical co- or counter-rotating screws is designed to minimize waste and reduce downtime necessary for cleaning.

  • Requires only 3g (4mL) of material for compounding
  • Small footprint, fanless design with separate, touch-screen control for operation in fume cabinet or glovebox applications
  • Removable and exchangeable product contact parts for quick and easy cleaning
  • IP 54 for protection against dust and water allows the Pharma mini HME to be spray-washed
  • Useable as small-scale production unit for throughputs of 100g/h
  • Touch screen control with user levels and password protection
  • Data logging software as option to record temperatures, torque, and screw speed
  • Optional batch conversion kit to use the Pharma mini HME as small batch mixer
  • Complementary workflow solution when coupled with the Thermo Scientific™ HAAKE™ MiniJet injection molder

Recommended for:


  • Pharmaceutical ingredients (API's)
  • Excipients
  • Medical polymers
  • Drug delivery systems
  • Soft gels


  • Hot melt extrusion
  • Medical devices
  • Implants
  • Controlled drug release
  • Handling and processing of highly potent API's in a glovebox

A small footprint reduces clean room volumes, and lower ingredient consumption reduces handling and operator exposure.


Pharma mini HME Micro Compounder Accessories

Accessories for the Pharma miniHME Micro Compounder used for Hot Melt Extrusion in research and development in the pharmaceutical industry.

Thermo Scientific™ CaliCut™ Post-extrusion System highlights:

  • Control precision: a 1D laser diameter gauge adjusts and pulls the strand enabling the diameter to be adjusted within set tolerances. A nominal strand diameter of 0.2 mm – 6 mm can be produced in conjunction with a nominal length of 1 mm – 200 mm.
  • Maximize flexibility: available with 350 mm, 700 mm or even 1200 mm belt lengths for cooling to meet a broad range of polymer formulation and throughput needs. Two different cutting mechanisms, a rotary and a linear cutting blade, optimize final implant sizing for a wide variety of implant materials. Make up to 600 cuts/minute.
  • Be 21 CFR part 11 compliant: stainless steel housing conforms to GMP guidelines while the software is used to control user access levels secures data export, and provide audit support. Documentation for IQ/OQ is provided.


HAAKE MiniCTW Micro-Conical Twin Screw Compounder

HAAKE MiniCTW Micro-Conical Twin Screw Compounder for industrial research and development needs a sample amount of 5g or 7cm3 only. Nobody can afford to waste expensive raw materials when developing new products. In addition, it helps to shorten time-to-market and cut development costs to gain a distinct competitive advantage. Therefore, quick and early assessments of a new material are key. The micro-conical twin screw compounder Thermo Scientific HAAKE MiniCTW allows extrudating as little as five grams of material and thereby helps to accelerate the conception of the final product.

When compounding expensive or small scale materials such as nano-composites or engineered polymers, you need a fast, dependable, cost efficient method to obtain tangible results.

Priced right, the HAAKE Mini CTW Micro-Conical Twin Screw Compounder is the answer: The HAAKE MiniCTW requires as little as five grams or seven milliliters (ml) of material for compounding, which is especially beneficial for industries that compound expensive or small-scale materials such as nano-composites, bio-polymers or pharmaceuticals. By using the optional force feeder, customers can continuously extrude very small material volumes. The instrument is based on proven, conical twin screw technology with co- and counter-rotating screws, and it works as a standalone unit with data export. Due to the channel and a backflow bypass valve, the residence time can be exactly defined.

The HAAKE MiniCTW Micro-Conical Twin Screw Compounder is ideal for the precisely controlled reactive extrusion of high-viscous melts that is being done via an MS-Windows™based software that offers several test set-ups. By running the instrument in circulation mode, the required reaction time for the reactive mixture can be controlled easily. At the end of the test, the bypass valve can be opened and the sample is extruded as a strand. By measuring the torque of the drive motor, the reaction process can be monitored effectively. Test results are stored in the software. The HAAKE MiniCTW Micro-Conical Twin Screw Compounder is one model within our suite of micro-conical twin screw compounders that serves a variety of markets, including polymer, bioscience, nanotechnology and pharmaceutical. The instrument differs from the well-established Thermo Scientific HAAKE MiniLab micro-compounder in that it is designed specifically for industrial research and development whereas the HAAKE MiniLab is focused on polymer development applications. To complete our comprehensive solutions, our international team of material characterization experts provides proven answers for small sample compounding.

Recommended for:

This miniaturized, high-tech tool is perfect for in industrial research in material science in the following markets:

  • Automotive
  • Aerospace
  • Electronics
  • Polymer Processing
  • Polymer Screening
  • Colorants
  • Specialty inks / Toners
  • Building and Construction
  • Consumer Products
  • Pulp and Paper

Product specification sheet



HAAKE MiniLab 3 Micro Compounder

Find unmatched flexibility in designing today's products for tomorrow's world. The Thermo Scientific™ HAAKE™ MiniLab 3 Micro Compounder provides extrusion specifications and online rheology measurements for pilot and scale-up projects across a range of compounded materials. 

Using material amounts as small as 5 grams, or 7 cm3, the HAAKE MiniLab 3 delivers meaningful results that enable you to streamline your new material development. Its screw speed and pressure range make it ideal for compounding expensive materials and for performing reactive extrusions.

Getting new compounds faster and documenting structural changes online has never been easier. The HAAKE MiniLab 3 Micro Compounder is a conical, twin-screw compounder with an integrated backflow channel. The compounder works as either a stand-alone unit or can be fully computer-controlled system, and can be used with either co- or counter-rotating screws. It is equipped with an inert gas flush system. Due to its channel and a bypass valve design, the residence time is well defined. Two pressure transducers are integrated in the backflow channel, which allow the measurement of relative melt viscosity when counter-rotating screws are used. Using the optional force feeder with the HAAKE MiniLab 3 Micro Compounder, continuous extrusion with very small volume flows is possible.

The HAAKE MiniLab 3 Micro Compounder Features:

  • Co- and counter-rotating twin screws
  • Integrated viscosity measurement (with HAAKE PolySoft OS)
  • Automatic bypass operation for circulation/extrusion
  • Pneumatic feeding
  • Local control via tablet (Android™) for  intuitive operation
  • Split barrel exit for easy cleaning
  • Compact enough to fit into laboratory fume hood

Recommended for material science research, such as testing expensive additives and developing new formulations.



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